The T-cell receptor signalosome: a dynamic structure with expanding complexity

Curr Opin Immunol. 2002 Jun;14(3):299-305. doi: 10.1016/s0952-7915(02)00339-4.


Signal transduction in T cells is a dynamic process involving a large number of membrane and cytosolic proteins. The TCR macromolecular complex (signalosome) is initiated by receptor occupancy and becomes more elaborate over time. This review describes how 'vertical' displacement mechanisms and lateral coalescence of lipid-raft-associated scaffold proteins combine to form distinct signalosomes, which control signal specificity.

Publication types

  • Review

MeSH terms

  • Animals
  • CD3 Complex / chemistry
  • CD3 Complex / physiology
  • Humans
  • Macromolecular Substances
  • Receptors, Antigen, T-Cell / chemistry
  • Receptors, Antigen, T-Cell / physiology*
  • Signal Transduction*
  • T-Lymphocytes / physiology*


  • CD3 Complex
  • Macromolecular Substances
  • Receptors, Antigen, T-Cell