Influence of effector molecules on the CD8(+) T cell response to infection

Curr Opin Immunol. 2002 Jun;14(3):360-5. doi: 10.1016/s0952-7915(02)00333-3.


Expansion and contraction of antigen-specific CD8(+) T cells after infection or vaccination results in stable memory. Recent evidence demonstrates that anti-microbial effector molecules such as perforin and IFN-gamma regulate specific aspects of CD8(+) T cell homeostasis by mechanisms that may be dependent or independent of pathogen clearance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • CD8-Positive T-Lymphocytes / immunology*
  • Cytokines / physiology
  • Homeostasis
  • Humans
  • Immunologic Memory
  • Infections / immunology*
  • Membrane Glycoproteins / physiology
  • Perforin
  • Pore Forming Cytotoxic Proteins


  • Cytokines
  • Membrane Glycoproteins
  • Pore Forming Cytotoxic Proteins
  • Perforin