Negative co-receptors on lymphocytes

Curr Opin Immunol. 2002 Jun;14(3):391-6. doi: 10.1016/s0952-7915(02)00341-2.

Abstract

The past year has seen significant advances in our understanding of critical roles of negative immunoregulatory signals delivered through the B7-CD28 superfamily in regulating T cell activation and tolerance. Structural data on CTLA-4 have provided novel insights into the inhibitory functions of CTLA-4. Initial characterization of the PD-1-PD-1-ligand pathway has revealed that this pathway can downregulate TCR- and CD28-mediated signals. Recent studies indicate that ICOS exerts distinct effects at different phases of an immune response: ICOS can inhibit as well as stimulate T cell responses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Abatacept
  • Animals
  • Antigens, CD
  • Antigens, Differentiation / physiology*
  • Antigens, Differentiation, T-Lymphocyte / physiology
  • Antigens, Surface / physiology
  • Apoptosis Regulatory Proteins
  • B7-1 Antigen / physiology*
  • B7-H1 Antigen
  • Blood Proteins*
  • CD28 Antigens / physiology*
  • CTLA-4 Antigen
  • Humans
  • Immunoconjugates*
  • Inducible T-Cell Co-Stimulator Protein
  • Intercellular Signaling Peptides and Proteins
  • Membrane Glycoproteins
  • Peptides / physiology
  • Programmed Cell Death 1 Ligand 2 Protein
  • Programmed Cell Death 1 Receptor
  • T-Lymphocytes / immunology*

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface
  • Apoptosis Regulatory Proteins
  • B7-1 Antigen
  • B7-H1 Antigen
  • Blood Proteins
  • CD274 protein, human
  • CD28 Antigens
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • ICOS protein, human
  • Immunoconjugates
  • Inducible T-Cell Co-Stimulator Protein
  • Intercellular Signaling Peptides and Proteins
  • Membrane Glycoproteins
  • PDCD1 protein, human
  • PDCD1LG2 protein, human
  • Peptides
  • Programmed Cell Death 1 Ligand 2 Protein
  • Programmed Cell Death 1 Receptor
  • Abatacept