The PE multigene family: a 'molecular mantra' for mycobacteria

Trends Microbiol. 2002 May;10(5):246-9. doi: 10.1016/s0966-842x(02)02335-1.

Abstract

The PE multigene family of Mycobacterium tuberculosis is remarkable in that it is composed of approximately 100 highly homologous genes that are found only in mycobacteria. Early evidence suggests that proteins encoded by certain members of this gene family could be present in the mycobacterial cell wall, impact antigen-presentation pathways and the ensuing host immune responses, and also provide a mechanism for generating antigenic diversity in mycobacteria.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigen Presentation
  • Antigens, Bacterial / chemistry
  • Antigens, Bacterial / genetics
  • Antigens, Bacterial / immunology
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / immunology
  • Humans
  • Membrane Proteins / chemistry
  • Membrane Proteins / genetics*
  • Membrane Proteins / immunology
  • Mice
  • Models, Genetic
  • Molecular Sequence Data
  • Multigene Family
  • Mycobacterium tuberculosis / genetics*
  • Mycobacterium tuberculosis / immunology
  • Sequence Analysis, Protein

Substances

  • Antigens, Bacterial
  • Bacterial Proteins
  • Membrane Proteins
  • PE-PGRS protein, Mycobacterium