Invasive filamentous growth of Candida albicans is promoted by Czf1p-dependent relief of Efg1p-mediated repression

Genetics. 2002 Apr;160(4):1749-53.

Abstract

Filamentation of Candida albicans occurs in response to many environmental cues. During growth within matrix, Efg1p represses filamentation and Czf1p relieves this repression. We propose that Czf1p interacts with Efg1p, altering its function. The complex regulation of filamentation may reflect the versatility of C. albicans as a pathogen.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Candida albicans / genetics
  • Candida albicans / growth & development*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Fungal Proteins / genetics
  • Fungal Proteins / physiology*
  • Temperature
  • Transcription Factors / genetics
  • Transcription Factors / physiology*
  • Two-Hybrid System Techniques

Substances

  • DNA-Binding Proteins
  • EFG1 protein, Candida albicans
  • Fungal Proteins
  • Transcription Factors
  • CZF1 protein, Candida albicans