Sexually transmitted diseases (STDs) which today are taken to cover all genital contact infections including the classical venereal diseases, have increased appreciably in recent years. With regard to the penis, STDs may manifest as papules, pustules and ulcers including urethral discharge and swelling of regional lymph nodes. Possible causes may be bacterial, viral or fungal. Depending on the pathogens involved, local or hematogeneous dissemination may occur. Treatment of infectious penile diseases follows the recommendations contained in the guidelines of the German Society for STD.