Derrisin, a new rotenoid from Derris malaccensis plain and anti-Helicobacter pylori activity of its related constituents

Junko Takashima; Noriko Chiba; Kaisuke Yoneda; Ayumi Ohsaki

doi:10.1021/np010126p

Derrisin, a new rotenoid from Derris malaccensis plain and anti-Helicobacter pylori activity of its related constituents

J Nat Prod. 2002 Apr;65(4):611-3. doi: 10.1021/np010126p.

Authors

Junko Takashima¹, Noriko Chiba, Kaisuke Yoneda, Ayumi Ohsaki

Affiliation

¹ Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, Aoba-ku, Yokohama 227-0033, Japan.

PMID: 11975515
DOI: 10.1021/np010126p

Abstract

A new rotenoid, derrisin (1), together with 10 known rotenoids (2-11) were isolated from the roots of Derris malaccensis Plain. The structure of 1 was elucidated by spectroscopic analysis. Nine of the isolated rotenoids (3-11) showed antibacterial activity against Helicobacter pylori.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Drugs, Chinese Herbal / chemistry*
Helicobacter pylori / drug effects
Heterocyclic Compounds, 4 or More Rings / chemistry
Heterocyclic Compounds, 4 or More Rings / isolation & purification*
Heterocyclic Compounds, 4 or More Rings / pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Roots / chemistry
Plants, Medicinal / chemistry*

Substances

Anti-Bacterial Agents
Drugs, Chinese Herbal
Heterocyclic Compounds, 4 or More Rings
derrisin