Abstract
[reaction: see text]. Silylated amino acids have been incorporated into peptides and then converted into N-acyliminium ions with the use of an anodic oxidation reaction. The result is a method for selectively incorporating conformational constraints or external nucleophiles within the peptide.
Publication types
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acids / chemical synthesis
-
Amino Acids / chemistry*
-
Cyclization
-
Indicators and Reagents
-
Lactams / chemical synthesis
-
Molecular Mimicry
-
Oxidation-Reduction
-
Peptides / chemical synthesis*
-
Silicon Compounds / chemistry*
Substances
-
Amino Acids
-
Indicators and Reagents
-
Lactams
-
Peptides
-
Silicon Compounds