Molecular and functional aspects of anionic channels activated during regulatory volume decrease in mammalian cells

Pflugers Arch. 2002 May;444(1-2):1-25. doi: 10.1007/s00424-002-0805-1. Epub 2002 Mar 8.


The ability of cells to readjust their volume after swelling, a phenomenon known as regulatory volume decrease (RVD), is a fundamental biological achievement guaranteeing survival and function of cells under osmotic stress. This article reviews the mechanisms of RVD in mammalian cells with special emphasis on the activation of ion channels during RVD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anions / metabolism*
  • Cell Physiological Phenomena*
  • Cell Size / physiology
  • Humans
  • Ion Channels / genetics
  • Ion Channels / physiology*


  • Anions
  • Ion Channels