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, 359 (9315), 1403-4

Hydronephrosis Associated With Retroperitoneal Fibrosis and Sclerosing Pancreatitis

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Case Reports

Hydronephrosis Associated With Retroperitoneal Fibrosis and Sclerosing Pancreatitis

Hideaki Hamano et al. Lancet.

Abstract

Sclerosing pancreatitis is associated with raised concentrations of IgG4. We treated 22 patients with sclerosing pancreatitis, and identified and followed-up three with concomitant hydronephrosis caused by ureteral mass, later diagnosed as retroperitoneal fibrosis. We histologically examined the ureteral and pancreatic lesions of these patients and noted abundant infiltration of IgG4-bearing plasma cells in both tissues. Treatment with corticosteroids lowered serum concentrations of IgG4. IgG4 might also have a pathological role in a systemic fibrosing process that includes pancreatic and retroperitoneal lesions.

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