Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors

Brain Res Mol Brain Res. 2002 Mar 28;99(2):145-9. doi: 10.1016/s0169-328x(02)00104-3.

Abstract

Protein kinase A (PKA) and neuronal nitric oxide synthase (nNOS) are important signaling molecules. It is well known that PKA can specifically phosphorylate nNOS. But the underlying molecular mechanism is still obscure. Our data indicate that the protein inhibitor of nNOS (PIN) binds to protein kinase A inhibitors (PKIs), which suggests that PKIs, together with PIN, might mediate the phosphorylation of nNOS by PKA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carrier Proteins / metabolism*
  • Cells, Cultured
  • Central Nervous System / enzymology*
  • Cyclic AMP-Dependent Protein Kinases / metabolism*
  • Drosophila Proteins*
  • Dyneins
  • Genes, Reporter / genetics
  • Humans
  • Intracellular Signaling Peptides and Proteins*
  • Nitrergic Neurons / enzymology*
  • Nitric Oxide / metabolism*
  • Nitric Oxide Synthase / metabolism*
  • Phosphorylation
  • Signal Transduction / genetics
  • Synaptic Transmission / physiology*
  • Two-Hybrid System Techniques
  • Yeasts / enzymology

Substances

  • Carrier Proteins
  • Drosophila Proteins
  • Intracellular Signaling Peptides and Proteins
  • protein kinase modulator
  • Nitric Oxide
  • Nitric Oxide Synthase
  • Cyclic AMP-Dependent Protein Kinases
  • Dyneins