Scleroderma and malignancy. Mechanisms of interrelationship

Eur J Dermatol. May-Jun 2002;12(3):296-300.

Abstract

The association of scleroderma and malignancy has been a source of controversy during recent years. Several mechanisms of interrelationship have been suggested in earlier reports. Recent long-term studies suggest an increased association-ratio of scleroderma and malignancy. However, the underlying mechanisms remain elusive. This paper reviews the mechanisms described in earlier studies and discusses their possible pathogenetic meaning for the interrelationship and the pathogenesis of scleroderma and neoplasia.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Antibiotics, Antineoplastic / adverse effects
  • Autoimmunity
  • Bleomycin / adverse effects
  • Breast Neoplasms / etiology
  • Cytokines / physiology
  • Disease Susceptibility
  • HLA-DR2 Antigen / analysis*
  • Humans
  • Immunity, Cellular
  • Neoplasms / drug therapy
  • Neoplasms / etiology*
  • Neoplasms / radiotherapy
  • Paraneoplastic Syndromes / pathology
  • Retrospective Studies
  • Scleroderma, Systemic / chemically induced
  • Scleroderma, Systemic / etiology*
  • Serotonin / physiology
  • Tryptophan / physiology

Substances

  • Antibiotics, Antineoplastic
  • Cytokines
  • HLA-DR2 Antigen
  • Bleomycin
  • Serotonin
  • Tryptophan