Late and chronic Lyme disease

Med Clin North Am. 2002 Mar;86(2):341-9, vii. doi: 10.1016/s0025-7125(03)00090-7.


This article reviews the late and chronic manifestations of Lyme disease. Special attention is given to the chronic manifestations of the disease, detailing its pathogenesis, clinical spectrum, and laboratory criteria for the diagnosis. Based on experimental evidence and experience, approaches to the successful treatment of the late and chronic disease are outlined. Much additional work is needed to improve the understanding of the underlying pathophysiology of the disease, its diagnosis and treatment.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Chronic Disease
  • Diagnosis, Differential
  • Humans
  • Lyme Disease / diagnosis*
  • Lyme Disease / drug therapy*
  • Time Factors


  • Anti-Bacterial Agents