Treatment-resistant depression: when antidepressant drug intolerance may indicate food intolerance

Aust N Z J Psychiatry. 2002 Apr;36(2):263-5. doi: 10.1046/j.1440-1614.2002.00978.x.


Objective: To describe a patient with food intolerance probably contributing to depressive symptoms, intolerance to psychotropic medication and treatment resistance.

Method: The case vignette and investigatory procedures are detailed.

Results: The patient's course improved considerably with an elimination diet.

Conclusions: The prevalence of food intolerance as a contributing factor to depressive disorders requires clarification. Clinicians should be aware of the possible syndrome and that it may be worsened by psychotropic medication.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antidepressive Agents / therapeutic use*
  • Depressive Disorder / drug therapy*
  • Depressive Disorder / psychology
  • Food Hypersensitivity / etiology*
  • Food Hypersensitivity / psychology*
  • Humans
  • Male
  • Treatment Failure


  • Antidepressive Agents