Diacylglycerol kinases: emerging downstream regulators in cell signaling systems

J Biochem. 2002 May;131(5):629-33. doi: 10.1093/oxfordjournals.jbchem.a003144.


Diacylglycerol kinase (DGK) regulates signal transduction by modulating the balance between the two signaling lipids, diacylglycerol and phosphatidic acid. DGK and its homologs occur in a wide range of multicellular organisms and the mammalian DGK is known to consist of nine members with a considerable incidence of alternative splicing. Recent work has established that DGK serves as a key attenuator of diacylglycerol of signaling functions and that the mammalian isozymes are equipped with molecular machineries which enable them to act in specific intracellular sites and/or in signaling protein complexes.

Publication types

  • Review

MeSH terms

  • Alternative Splicing / genetics
  • Animals
  • Caenorhabditis elegans Proteins*
  • Carrier Proteins
  • Conserved Sequence
  • Diacylglycerol Kinase / genetics
  • Diacylglycerol Kinase / metabolism
  • Diacylglycerol Kinase / physiology*
  • Diglycerides / metabolism
  • Isoenzymes / genetics
  • Isoenzymes / metabolism
  • Isoenzymes / physiology
  • Phosphatidic Acids / metabolism
  • Phosphorylation
  • Protein Kinase C / metabolism
  • Receptors, Drug / metabolism
  • Signal Transduction / physiology*
  • Tyrosine / metabolism


  • Caenorhabditis elegans Proteins
  • Carrier Proteins
  • Diglycerides
  • Isoenzymes
  • Phosphatidic Acids
  • Receptors, Drug
  • phorbol ester binding protein
  • phorbol ester receptor
  • Tyrosine
  • Diacylglycerol Kinase
  • Protein Kinase C