Abstract
The presentation of peptides to T cells by MHC class II molecules is of critical importance in specific recognition by the immune system. Expression of class II molecules is exquisitely controlled at the transcriptional level. A large set of proteins interact with the promoters of class II genes. The most important of these is CIITA, a master controller that orchestrates expression but does not bind directly to the promoter. The transcriptosome complex formed at class II promoters is a model for induction of gene expression.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens, Differentiation, B-Lymphocyte / metabolism
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Gene Expression Regulation*
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Genes, MHC Class II / genetics*
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Histocompatibility Antigens Class II / genetics
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Histocompatibility Antigens Class II / metabolism
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Humans
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Immune System Diseases
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Macromolecular Substances
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Nuclear Proteins*
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Polymorphism, Genetic / genetics
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Promoter Regions, Genetic / genetics
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Severe Combined Immunodeficiency / immunology
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Trans-Activators / chemistry
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Trans-Activators / genetics
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Trans-Activators / metabolism
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Transcription Factors / metabolism
Substances
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Antigens, Differentiation, B-Lymphocyte
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Histocompatibility Antigens Class II
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MHC class II transactivator protein
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Macromolecular Substances
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Nuclear Proteins
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Trans-Activators
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Transcription Factors
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invariant chain