Missing Pieces in the NF-kappaB Puzzle

Cell. 2002 Apr;109 Suppl:S81-96. doi: 10.1016/s0092-8674(02)00703-1.

Abstract

The regulation of the transcription factor NF-kappaB activity occurs at several levels including controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A critical component in NF-kappaB regulation is the IkappaB kinase (IKK) complex. This review is focused on recent progress as well as unanswered questions regarding the regulation and function of NF-kappaB and IKK.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • Catalytic Domain
  • Cell Nucleus / metabolism
  • Cytoplasm / metabolism
  • Enzyme Activation
  • Gene Expression Regulation
  • Humans
  • I-kappa B Kinase
  • NF-kappa B / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism
  • Signal Transduction

Substances

  • NF-kappa B
  • Protein-Serine-Threonine Kinases
  • CHUK protein, human
  • I-kappa B Kinase
  • IKBKB protein, human
  • IKBKE protein, human