Transcription: tantalizing times for T cells

Cell. 2002 Apr;109 Suppl:S109-20. doi: 10.1016/s0092-8674(02)00705-5.

Abstract

The T helper lymphocyte is responsible for orchestrating an appropriate immune response to pathogens. To do so, it has evolved into two specialized subsets that direct type 1 and type 2 immunity. Here, we discuss the genetic programs that control lineage commitment of progenitor T helper cells along each of these pathways.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation*
  • Cell Lineage*
  • Cytokines / genetics
  • DNA-Binding Proteins / metabolism
  • GATA3 Transcription Factor
  • Gene Expression Regulation*
  • Humans
  • NFATC Transcription Factors
  • Nuclear Proteins*
  • Protein Processing, Post-Translational
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-maf
  • STAT6 Transcription Factor
  • T-Box Domain Proteins
  • T-Lymphocytes / cytology*
  • T-Lymphocytes / metabolism*
  • Trans-Activators / metabolism
  • Transcription Factors / metabolism
  • Transcription, Genetic

Substances

  • Cytokines
  • DNA-Binding Proteins
  • GATA3 Transcription Factor
  • GATA3 protein, human
  • MAF protein, human
  • NFATC Transcription Factors
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-maf
  • STAT6 Transcription Factor
  • STAT6 protein, human
  • T-Box Domain Proteins
  • T-box transcription factor TBX21
  • Trans-Activators
  • Transcription Factors