Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

Cell. 2002 Apr;109 Suppl:S121-31. doi: 10.1016/s0092-8674(02)00701-8.

Abstract

The importance of Jak-Stat pathway signaling in regulating cytokine-dependent gene expression and cellular development/survival is well established. Nevertheless, advances continue to be made in defining Jak-Stat pathway effects on different cellular processes and in different organisms. This review focuses on recent advances in the field and highlights some of the most active areas of Jak-Stat pathway research.

Publication types

  • Review

MeSH terms

  • Animals
  • Carrier Proteins / metabolism
  • Cytokines / metabolism*
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism*
  • Gene Expression Regulation
  • Humans
  • Intracellular Signaling Peptides and Proteins*
  • Janus Kinase 1
  • Methylation
  • Protein Inhibitors of Activated STAT
  • Protein-Tyrosine Kinases / metabolism*
  • Proteins / metabolism
  • Receptors, Cytokine / metabolism
  • Repressor Proteins*
  • STAT1 Transcription Factor
  • Signal Transduction*
  • Suppressor of Cytokine Signaling 1 Protein
  • Suppressor of Cytokine Signaling Proteins
  • Trans-Activators / chemistry
  • Trans-Activators / metabolism*

Substances

  • Carrier Proteins
  • Cytokines
  • DNA-Binding Proteins
  • Intracellular Signaling Peptides and Proteins
  • Protein Inhibitors of Activated STAT
  • Proteins
  • Receptors, Cytokine
  • Repressor Proteins
  • SOCS1 protein, human
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • Suppressor of Cytokine Signaling 1 Protein
  • Suppressor of Cytokine Signaling Proteins
  • Trans-Activators
  • Protein-Tyrosine Kinases
  • JAK1 protein, human
  • Janus Kinase 1