Association of 5-HT(2A) receptor gene polymorphism with major affective disorders: the case of a subgroup of bipolar disorder with low suicide risk

Biol Psychiatry. 2002 May 1;51(9):762-5. doi: 10.1016/s0006-3223(01)01228-8.


Background: The implication of serotonin in suicide and affective disease explains why the 5-HT(2A) receptor gene has been proposed as a candidate gene in these disorders, although with conflicting results.

Methods: We analysed the distribution of the 5-HT(2A)-1438A/G genetic polymorphism in 192 patients with major affective disorder (127 bipolar disorders and 65 unipolar disorders) compared to 142 healthy control subjects.

Results: We found a higher frequency of the A allele in affected patients than in control subjects (p =.034), this difference being particularly striking for the subgroup of patients with type I bipolar disorder (p =.015). Patients with no personal and/or familial history of suicide attempts mainly accounted for the excess of the A allele in affected patients.

Conclusions: The association detected in this study suggests that the 5-HT(2A) receptor gene may play a role in the genetic susceptibility to bipolar disorder, through a specific subgroup of bipolar type I patients with lower risk of suicidal behavior.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Bipolar Disorder / genetics*
  • Bipolar Disorder / psychology*
  • Female
  • France
  • Humans
  • Male
  • Mood Disorders / genetics*
  • Mood Disorders / psychology*
  • Polymorphism, Genetic / genetics*
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Serotonin / genetics*
  • Risk
  • Suicide / psychology*


  • Receptor, Serotonin, 5-HT2A
  • Receptors, Serotonin