Divalproex in the management of neuropsychiatric complications of remote acquired brain injury

J Neuropsychiatry Clin Neurosci. Spring 2002;14(2):202-5. doi: 10.1176/jnp.14.2.202.


A retrospective chart review was conducted on 11 patients with a remote history of acquired brain injury (ABI) referred for psychiatric treatment who were treated with divalproex sodium alone or in combination with other psychotropic medications. The patients were highly heterogeneous. They had a variety of psychiatric symptoms and frequently received concomitant psychotropic medications. The mean daily dose of divalproex was 1,818+/-791 mg/day, serum valproic acid level 85.6+/-29.6 microg/ml. Mean Clinical Global Impression improvement score was 1.9+/-0.5. This is the largest postacute case series reported. It demonstrates that divalproex sodium is well tolerated and effective in reducing a broad range of neurobehavioral symptoms in psychiatric patients with a remote history of ABI.

MeSH terms

  • Adolescent
  • Adult
  • Anticonvulsants / blood
  • Anticonvulsants / therapeutic use*
  • Bipolar Disorder / drug therapy*
  • Bipolar Disorder / etiology*
  • Brain Injuries / psychology*
  • Child
  • Child, Preschool
  • Depressive Disorder, Major / drug therapy*
  • Depressive Disorder, Major / etiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Psychotic Disorders / drug therapy*
  • Psychotic Disorders / etiology*
  • Retrospective Studies
  • Valproic Acid / therapeutic use*


  • Anticonvulsants
  • Valproic Acid