[Disturbance of lipid metabolism]

Rinsho Byori. 2002 Mar;50(3):219-25.
[Article in Japanese]

Abstract

The disturbance of lipid metabolism is seen in some inherited diseases and also in patients with some kinds of underlying diseases. The presence of its disturbance can be detected by measuring the concentrations of cholesterol and triglyceride in serum. Although hyperlipidemia or hypolipidemia is the result of abnormal lipid metabolism, hyperlipidemia is of more concern to physicians because of the close association with atherosclerosis. Responsible genes for some primary (or hereditary) hyperlipidemic diseases have been confirmed as follows; LPL or apo C-II for primary chylomicronemia, LDL receptor for familial hypercholesterolemia and apo B-100 for familial defective apo B-100. However, the responsible gene remains controversial for familial combined hyperlipidemia, though AI/CIII/AIV cluster is one of the possible candidate genes. Secondary hyperlipidemia is caused by various diseases such as diabetes mellitus, renal diseases and cholestasis. This type of hyperlipidemia is improved by therapy for the underlying diseases. To date, the mechanism of lipid metabolism has been defined in a molecular basis. In fact, sterol regulatory element-binding protein (SREBP), peroxisome proliferator-activated receptor (PPAR) and ATP-binding cassette transporter subfamily A, member 1(ABCA1) were recently identified and it was demonstrated that these regulate lipid metabolism.

MeSH terms

  • ATP Binding Cassette Transporter 1
  • ATP-Binding Cassette Transporters / genetics
  • CCAAT-Enhancer-Binding Proteins / physiology
  • Cholesterol, HDL / blood
  • DNA-Binding Proteins / physiology
  • Humans
  • Hyperlipidemias / diagnosis*
  • Hyperlipidemias / etiology
  • Hyperlipidemias / genetics
  • Hyperlipoproteinemia Type II / diagnosis
  • Lipid Metabolism*
  • Receptors, Cytoplasmic and Nuclear / physiology
  • Sterol Regulatory Element Binding Protein 1
  • Transcription Factors / physiology

Substances

  • ABCA1 protein, human
  • ATP Binding Cassette Transporter 1
  • ATP-Binding Cassette Transporters
  • CCAAT-Enhancer-Binding Proteins
  • Cholesterol, HDL
  • DNA-Binding Proteins
  • Receptors, Cytoplasmic and Nuclear
  • SREBF1 protein, human
  • Sterol Regulatory Element Binding Protein 1
  • Transcription Factors