Evolution of colorectal cancer: change of pace and change of direction

J Gastroenterol Hepatol. 2002 Jan;17(1):17-26. doi: 10.1046/j.1440-1746.2002.02635.x.


This review compiles evidence for an alternative to the classical adenoma-carcinoma sequence in the evolution of colorectal cancer. It is suggested that between 30 and 50 of colorectal cancers are not initiated by mutation of the tumor suppressor gene APC, but through the epigenetic silencing of genes implicated in the control of differentiation, cell cycle control and DNA repair proficiency. The precursor polyps are often characterized by a serrated architecture, and include hyperplastic polyps, admixed polyps and serrated adenomas. The alternative pathway is heterogeneous and may culminate in cancers showing low or high level DNA microsatellite instability (MSI-L and MSI-H, respectively), and in cancers that are microsatellite stable (MSS). Cancers showing DNA MSI may be characterized by an accelerated evolution. Cancers in hereditary non-polyposis colorectal cancer show features of both classical (adenoma and APC mutation) and alternative pathways (rapid evolution, MSI-H and lack of chromosomal instability).

Publication types

  • Review

MeSH terms

  • Adenoma / genetics*
  • Adenoma / physiopathology
  • Base Pair Mismatch
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / physiopathology
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
  • Colorectal Neoplasms, Hereditary Nonpolyposis / physiopathology
  • DNA Methylation
  • DNA Repair
  • Disease Progression
  • Genes, APC
  • Genes, p53
  • Genes, ras
  • Humans
  • Microsatellite Repeats*
  • Mutation*
  • Neoplasm, Residual