Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: results of a 2-year prospective randomised multicentre study (INCOMIN)

Lancet. 2002 Apr 27;359(9316):1453-60. doi: 10.1016/s0140-6736(02)08430-1.


Background: The three interferon beta preparations approved for treatment of relapsing-remitting multiple sclerosis (MS) differ in dose and frequency of administration. Interferon beta-1a 30 microg is administered once a week, interferon beta-1a 22 microg or 44 microg is given three times a week, and interferon beta-1b 250 microg is administered on alternate days. No clinical study directly comparing the different regimens has been published. The INCOMIN study was designed to compare the clinical and magnetic resonance imaging (MRI) benefits of on-alternate-day interferon beta-1b 250 microg with once-weekly interferon beta-1a 30 microg.

Methods: INCOMIN was a 2-year, prospective, randomised, multicentre study. 188 patients with relapsing-remitting MS were assigned to interferon beta-1b (n=96) or interferon beta-1a (n=92). Primary outcome measures were the proportion of patients free from relapses and that of patients free from new proton density/T2 lesions at MRI assessment. Several secondary outcome measures were also assessed. Analysis was by intention to treat.

Findings: Over 2 years, 49 (51%) individuals administered interferon beta-1b remained relapse-free compared with 33 (36%) given interferon beta-1a relative risk of relapse 0.76; 95% CI 0.59-0.9; p=0.03); and 42 (55%) compared with 19 (26%), respectively, remained free from new T2 lesions at MRI (relative risk of new T2 lesion 0.6; 0.45-0.8; p<0.0003). In both groups, the differences between the two treatments increased during the second year. There were also significant differences in favour of interferon beta-1b in most of the secondary outcome measures, including delay of confirmed disease progression.

Interpretation: High-dose interferon beta-1b administered every other day is more effective than interferon beta-1a given once a week.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / adverse effects
  • Adjuvants, Immunologic / therapeutic use*
  • Adult
  • Depression / chemically induced
  • Disease Progression
  • Drug Administration Schedule
  • Fatigue / chemically induced
  • Female
  • Fever / chemically induced
  • Follow-Up Studies
  • Humans
  • Interferon beta-1a
  • Interferon beta-1b
  • Interferon-beta / adverse effects
  • Interferon-beta / therapeutic use*
  • Liver / drug effects
  • Liver / enzymology
  • Male
  • Multiple Sclerosis / drug therapy*
  • Multiple Sclerosis / pathology
  • Prospective Studies
  • Recurrence
  • Time Factors
  • Treatment Outcome


  • Adjuvants, Immunologic
  • Interferon beta-1b
  • Interferon-beta
  • Interferon beta-1a