Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants

Lancet. 2002 Apr 27;359(9316):1486-8. doi: 10.1016/S0140-6736(02)08424-6.


We report three cases of severe hypoxaemia after ibuprofen administration during a randomised controlled trial of prophylactic treatment of patent ductus arteriosus with ibuprofen in premature infants born at less than 28 weeks of gestation. Echocardiography showed severely decreased pulmonary blood flow. Hypoxaemia resolved quickly on inhaled nitric oxide therapy. We suggest that investigators involved in similar trials pay close attention to pulmonary pressure if hypoxaemia occurs after prophylactic administration of ibuprofen.

Publication types

  • Case Reports
  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics, Non-Narcotic / adverse effects*
  • Analgesics, Non-Narcotic / therapeutic use
  • Ductus Arteriosus, Patent / prevention & control
  • Electrocardiography
  • Humans
  • Hypertension, Pulmonary / chemically induced*
  • Ibuprofen / adverse effects*
  • Ibuprofen / therapeutic use
  • Infant, Newborn
  • Infant, Premature
  • Pulmonary Artery / drug effects
  • Pulmonary Artery / physiopathology
  • Randomized Controlled Trials as Topic


  • Analgesics, Non-Narcotic
  • Ibuprofen