Conformational dynamics of the chromatin fiber in solution: determinants, mechanisms, and functions

Annu Rev Biophys Biomol Struct. 2002;31:361-92. doi: 10.1146/annurev.biophys.31.101101.140858. Epub 2001 Oct 25.

Abstract

Chromatin fibers are dynamic macromolecular assemblages that are intimately involved in nuclear function. This review focuses on recent advances centered on the molecular mechanisms and determinants of chromatin fiber dynamics in solution. Major points of emphasis are the functions of the core histone tail domains, linker histones, and a new class of proteins that assemble supramolecular chromatin structures. The discussion of important structural issues is set against a background of possible functional significance.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / metabolism
  • Chromatin / chemistry
  • DNA / chemistry*
  • Histones / chemistry*
  • Humans
  • Models, Biological
  • Models, Chemical
  • Protein Conformation
  • Structure-Activity Relationship

Substances

  • Chromatin
  • Histones
  • DNA