The origins of protein phosphorylation

Nat Cell Biol. 2002 May;4(5):E127-30. doi: 10.1038/ncb0502-e127.


The reversible phosphorylation of proteins is central to the regulation of most aspects of cell function but, even after the first protein kinase was identified, the general significance of this discovery was slow to be appreciated. Here I review the discovery of protein phosphorylation and give a personal view of the key findings that have helped to shape the field as we know it today.

Publication types

  • Historical Article
  • Portrait
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cyclic AMP / history
  • Cyclic AMP / metabolism
  • Glycogen / history
  • Glycogen / metabolism
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Nobel Prize
  • Phosphorylation
  • Protein Kinases / history*
  • Protein Kinases / metabolism
  • Proteins / history*
  • Proteins / metabolism


  • Proteins
  • Glycogen
  • Cyclic AMP
  • Protein Kinases