Life is a journey: a genetic look at neocortical development

Nat Rev Genet. 2002 May;3(5):342-55. doi: 10.1038/nrg799.

Abstract

Although the basic principles of neocortical development have been known for quite some time, it is only recently that our understanding of the molecular mechanisms that are involved has improved. Such understanding has been facilitated by genetic approaches that have identified key proteins involved in neocortical development, which have been placed into signalling pathways by molecular and cell-biological studies. The challenge of current research is to understand the manner in which these various signalling pathways are interconnected to gain a more comprehensive picture of the molecular intricacies that govern neocortical development.

Publication types

  • Review

MeSH terms

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase
  • Animals
  • Cell Adhesion Molecules, Neuronal / physiology
  • Cell Movement / genetics*
  • Cell Movement / physiology
  • Cyclin-Dependent Kinase 5
  • Cyclin-Dependent Kinases / physiology
  • Dyneins / physiology
  • Extracellular Matrix Proteins / physiology
  • Mice
  • Mice, Mutant Strains / physiology
  • Microtubule-Associated Proteins / genetics
  • Microtubule-Associated Proteins / physiology
  • Neocortex / embryology*
  • Neocortex / physiology*
  • Nerve Tissue Proteins
  • Neurons / physiology
  • Neuropeptides / genetics
  • Neuropeptides / physiology
  • Serine Endopeptidases
  • Signal Transduction / genetics*
  • Signal Transduction / physiology

Substances

  • Cell Adhesion Molecules, Neuronal
  • Extracellular Matrix Proteins
  • Microtubule-Associated Proteins
  • Nerve Tissue Proteins
  • Neuropeptides
  • doublecortin protein
  • Cyclin-Dependent Kinase 5
  • Cdk5 protein, mouse
  • Cyclin-Dependent Kinases
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase
  • Pafah1b1 protein, mouse
  • Serine Endopeptidases
  • reelin protein
  • Dyneins