Abstract
Peroxisomal enzymes are synthesized in the cytoplasm and imported post-translationally across the peroxisome membrane. Unlike other organelles with a sealed membrane, peroxisomes can import folded enzymes, and they seem to lack intraperoxisomal chaperones. Here, we propose a mechanistic model for the early steps in peroxisomal-matrix-enzyme import, which might help to explain the unusual features of this process.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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ATPases Associated with Diverse Cellular Activities
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Adenosine Triphosphatases / metabolism
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Animals
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Carrier Proteins / metabolism
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Macromolecular Substances
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Membrane Proteins / metabolism
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Membrane Transport Proteins
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Peroxins
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Peroxisome-Targeting Signal 1 Receptor
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Peroxisomes / physiology*
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Protein Transport / physiology*
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Receptors, Cytoplasmic and Nuclear / metabolism
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Repressor Proteins*
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Saccharomyces cerevisiae / physiology
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Saccharomyces cerevisiae / ultrastructure
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Saccharomyces cerevisiae Proteins*
Substances
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Carrier Proteins
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Macromolecular Substances
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Membrane Proteins
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Membrane Transport Proteins
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PEX14 protein, S cerevisiae
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Peroxins
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Peroxisome-Targeting Signal 1 Receptor
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Receptors, Cytoplasmic and Nuclear
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Repressor Proteins
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Saccharomyces cerevisiae Proteins
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Adenosine Triphosphatases
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ATPases Associated with Diverse Cellular Activities
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PEX6 protein, S cerevisiae
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PEX6 protein, human
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Pex6 protein, rat