Synthesis and anticonvulsant activity of some omega-(1H-1-imidazolyl)-N-phenylalkanoic acid amide derivatives

Farmaco. 2002 Mar;57(3):201-6. doi: 10.1016/s0014-827x(01)01197-1.

Abstract

In this study, 15 omega-(1H-imidazol-1-yl)-N-phenylacetamide, propionamide and butyramide derivatives having methoxyl, methyl, nitro and chloro in ortho position of N-phenyl ring or without any substituent have been realized by two-step synthesis. Their anticonvulsant activity was determined against seizures induced by maximal electroshock (MES). The most active compound in the series was 2-(1H-imidazol-1-yl)-N-(o-chlorophenyl)acetamide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemical synthesis*
  • Amides / chemistry
  • Amides / pharmacology*
  • Amides / toxicity
  • Animals
  • Anticonvulsants / chemical synthesis*
  • Anticonvulsants / chemistry
  • Anticonvulsants / pharmacology*
  • Anticonvulsants / toxicity
  • Electroshock
  • Female
  • Imidazoles / chemical synthesis*
  • Imidazoles / chemistry
  • Imidazoles / pharmacology*
  • Imidazoles / toxicity
  • Magnetic Resonance Spectroscopy
  • Mice
  • Seizures / drug therapy
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Structure-Activity Relationship

Substances

  • Amides
  • Anticonvulsants
  • Imidazoles