Emerging molecular markers of cancer

Nat Rev Cancer. 2002 Mar;2(3):210-9. doi: 10.1038/nrc755.


Alterations in gene sequences, expression levels and protein structure or function have been associated with every type of cancer. These 'molecular markers' can be useful in detecting cancer, determining prognosis and monitoring disease progression or therapeutic response. But what is the best way to identify molecular markers and can they be easily incorporated into the clinical setting?

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • DNA / blood
  • Genetic Markers*
  • Humans
  • Mutation
  • Neoplasms / genetics*
  • Oligonucleotide Array Sequence Analysis
  • Sensitivity and Specificity


  • Genetic Markers
  • DNA