History of Haematopoietic Stem-Cell Transplantation

Nat Rev Cancer. 2002 Mar;2(3):231-8. doi: 10.1038/nrc748.


After fifty years of investigations into the use of pluripotent haematopoietic stem-cell transplantation for cancer therapy, this procedure has progressed from one that was thought to be plagued with insurmountable complications to a standard treatment for many haematological malignancies. How have these hurdles been overcome, and how can the therapy be expanded to include patients who are too old or medically infirm to tolerate conventional transplant approaches?

Publication types

  • Historical Article
  • Review

MeSH terms

  • Hematologic Neoplasms / history*
  • Hematologic Neoplasms / therapy
  • Hematopoietic Stem Cell Transplantation / history*
  • Hematopoietic Stem Cells / physiology
  • History, 20th Century
  • Humans