Effects of extracorporeal circulation on thrombinantithrombin III and prothrombin fragment 1+2 levels

Clin Appl Thromb Hemost. 2002 Jan;8(1):61-3. doi: 10.1177/107602960200800108.


Cardiopulmonary bypass may alter the factors responsible for normal hemostasis by exposing blood to nonendothelial surfaces, for example, extracorporeal circuits. To evaluate the probable effect of extracorporeal circulation on hemostasis, we measured thrombin-antithrombin III complex (TAT) and prothrombin fragment 1+2 (PF 1.2) plasma levels, which are the biologic markers of in vivo coagulation, in 20 patients who underwent coronary artery bypass grafting (CABG). Postoperative PF 1.2 levels were higher in comparison to the preoperative concentrations of the parameter. Preoperative and postoperative TAT concentrations showed no statistically significant difference. The increment in the PF 1.2 levels in CABG patients might suggest ongoing subclinical hemostatic activation associated with CABG. Further investigations are needed to clarify the exact relationship between increased PF 1.2 levels and thrombotic complications observed in CABG patients. Hemostatis in CABG is still an enigma and remains to be eluciated.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Antithrombin III
  • Biomarkers / blood
  • Cardiopulmonary Bypass
  • Extracorporeal Circulation*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Peptide Fragments / blood*
  • Peptide Hydrolases / blood*
  • Postoperative Period
  • Prothrombin


  • Biomarkers
  • Peptide Fragments
  • antithrombin III-protease complex
  • prothrombin fragment 1.2
  • Antithrombin III
  • Prothrombin
  • Peptide Hydrolases