Treatment of varicose and telangiectatic leg veins: double-blind prospective comparative trial between aethoxyskerol and sotradecol

Dermatol Surg. 2002 Jan;28(1):52-5. doi: 10.1046/j.1524-4725.2002.01190.x.


Background: One hundred twenty-nine patients were treated with either polidocanol (POL) or sodium tetradecyl sulfate (STS) to compare the efficacy and adverse sequelae of each agent.

Objective: To determine the safety and efficacy of two sclerosing solutions.

Methods: Each patient's leg veins that did not have incompetence from the saphenofemoral junction (SFJ) were divided into three categories by size (<1 mm, 1-3 mm, 3-6 mm). Each leg was randomly treated with either 0.25%, 0.5%, or 1.5% of STS or 0.5%, 1.0%, or 3% of POL respective of size. An independent, three-panel, blindly randomized photographic examination was obtained pretreatment and at 4 and 16 weeks. Patient satisfaction index and overall clinical improvement assessment were also obtained.

Results: All patients had an average of 70% improvement and were 70-72% satisfied in all vein categories treated with either solution. There was no significant difference in adverse effects between each group except for a decrease in ulcerations and swelling in the POL group.

Conclusion: Both STS and POL are safe and effective sclerosing solutions for varicose and telangiectatic leg veins.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Double-Blind Method
  • Humans
  • Leg / blood supply*
  • Polidocanol
  • Polyethylene Glycols / therapeutic use*
  • Prospective Studies
  • Sclerosing Solutions / therapeutic use*
  • Sclerotherapy / methods*
  • Sodium Tetradecyl Sulfate / therapeutic use*
  • Telangiectasis / therapy*
  • Treatment Outcome
  • Varicose Veins / therapy*


  • Sclerosing Solutions
  • Polidocanol
  • Polyethylene Glycols
  • Sodium Tetradecyl Sulfate