Therapeutic use of cytokines to modulate phagocyte function for the treatment of infectious diseases: current status of granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and interferon-gamma

J Infect Dis. 2002 May 15;185(10):1490-501. doi: 10.1086/340221. Epub 2002 Apr 19.

Abstract

The innate immune system represents the initial arm of host defense against pathogenic bacteria, fungi, and parasites. Neutrophils, monocytes, and tissue-based macrophages are major cellular components of this system. The potential ability to augment activity of the innate immune system has increased dramatically during the past 2 decades, with the discovery and development of cytokines. Four cytokines, namely granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), and interferon (IFN)-gamma, have received increasing attention as potential adjunctive agents for the treatment of infectious diseases. In various animal models of infection, therapeutic administration of each of the 4 cytokines has been shown to enhance pathogen eradication and to decrease morbidity and/or mortality. However, variable therapeutic efficacy has been reported in clinical trials conducted to date. This review summarizes the current status of the use of G-CSF, GM-CSF, M-CSF, and IFN-gamma in the treatment of infectious diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chills / etiology
  • Clinical Trials as Topic
  • Communicable Diseases / immunology
  • Communicable Diseases / therapy*
  • Disease Models, Animal
  • Fever / etiology
  • Granulocyte Colony-Stimulating Factor / adverse effects
  • Granulocyte Colony-Stimulating Factor / therapeutic use*
  • Granulocyte-Macrophage Colony-Stimulating Factor / adverse effects
  • Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use*
  • Headache / etiology
  • Humans
  • Interferon-gamma / therapeutic use*
  • Macrophage Colony-Stimulating Factor / adverse effects
  • Macrophage Colony-Stimulating Factor / therapeutic use*
  • Pain / etiology
  • Phagocytes / drug effects*
  • Phagocytes / immunology
  • Thrombocytopenia / etiology

Substances

  • Granulocyte Colony-Stimulating Factor
  • Macrophage Colony-Stimulating Factor
  • Interferon-gamma
  • Granulocyte-Macrophage Colony-Stimulating Factor