Phosphotyrosine-binding domains in signal transduction

Nat Rev Mol Cell Biol. 2002 Mar;3(3):177-86. doi: 10.1038/nrm759.


Protein phosphorylation provides molecular control of complex physiological events within cells. In many cases, phosphorylation on specific amino acids directly controls the assembly of multi-protein complexes by recruiting phospho-specific binding modules. Here, the function, structure, and cell biology of phosphotyrosine-binding domains is discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Humans
  • Ligands
  • Models, Biological
  • Models, Molecular
  • Phosphotyrosine / metabolism*
  • Protein Structure, Tertiary
  • Receptors, Growth Factor / chemistry
  • Receptors, Growth Factor / physiology
  • Signal Transduction / physiology*
  • src Homology Domains


  • Ligands
  • Receptors, Growth Factor
  • Phosphotyrosine