Review
doi: 10.1038/nrm760.
Messenger-RNA-binding proteins and the messages they carry
Affiliations
- PMID: 11994740
- DOI: 10.1038/nrm760
Item in Clipboard
Review
Messenger-RNA-binding proteins and the messages they carry
Nat Rev Mol Cell Biol.
2002 Mar.
Abstract
From sites of transcription in the nucleus to the outreaches of the cytoplasm, messenger RNAs are associated with RNA-binding proteins. These proteins influence pre-mRNA processing as well as the transport, localization, translation and stability of mRNAs. Recent discoveries have shown that one group of these proteins marks exon exon junctions and has a role in mRNA export. These proteins communicate crucial information to the translation machinery for the surveillance of nonsense mutations and for mRNA localization and translation.
Similar articles
-
Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex.Science. 2001 Sep 7;293(5536):1832-6. doi: 10.1126/science.1062829. Science. 2001. PMID: 11546873
-
A new view of mRNA export: separating the wheat from the chaff.Nat Cell Biol. 2001 Sep;3(9):E201-4. doi: 10.1038/ncb0901-e201. Nat Cell Biol. 2001. PMID: 11533670 Review.
-
The Y14 protein communicates to the cytoplasm the position of exon-exon junctions.EMBO J. 2001 Apr 17;20(8):2062-8. doi: 10.1093/emboj/20.8.2062. EMBO J. 2001. PMID: 11296238 Free PMC article.
-
Quality control of messenger ribonucleoprotein particles in the nucleus and at the pore.Curr Opin Cell Biol. 2005 Jun;17(3):294-301. doi: 10.1016/j.ceb.2005.04.007. Curr Opin Cell Biol. 2005. PMID: 15901500 Review.
-
The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.EMBO J. 2001 Sep 3;20(17):4987-97. doi: 10.1093/emboj/20.17.4987. EMBO J. 2001. PMID: 11532962 Free PMC article.
Cited by
-
ELAVL1 primarily couples mRNA stability with the 3' UTRs of interferon-stimulated genes.Cell Rep. 2021 May 25;35(8):109178. doi: 10.1016/j.celrep.2021.109178. Cell Rep. 2021. PMID: 34038724 Free PMC article.
-
Identification and Validation of an Immune-Associated RNA-Binding Proteins Signature to Predict Clinical Outcomes and Therapeutic Responses in Glioma Patients.Cancers (Basel). 2021 Apr 6;13(7):1730. doi: 10.3390/cancers13071730. Cancers (Basel). 2021. PMID: 33917399 Free PMC article.
-
Alterations in RNA processing during immune-mediated programmed cell death.Proc Natl Acad Sci U S A. 2012 May 29;109(22):8688-93. doi: 10.1073/pnas.1201327109. Epub 2012 May 15. Proc Natl Acad Sci U S A. 2012. PMID: 22589304 Free PMC article.
-
Molecular Characterization, Expression Pattern and Function Analysis of Glycine-Rich Protein Genes Under Stresses in Chinese Cabbage (Brassica rapa L. ssp. pekinensis).Front Genet. 2020 Jul 23;11:774. doi: 10.3389/fgene.2020.00774. eCollection 2020. Front Genet. 2020. PMID: 32849790 Free PMC article.
-
Role of RNA structure motifs in IRES-dependent translation initiation of the coxsackievirus B3: new insights for developing live-attenuated strains for vaccines and gene therapy.Mol Biotechnol. 2013 Oct;55(2):179-202. doi: 10.1007/s12033-013-9674-4. Mol Biotechnol. 2013. PMID: 23881360 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
