Messenger-RNA-binding proteins and the messages they carry

Nat Rev Mol Cell Biol. 2002 Mar;3(3):195-205. doi: 10.1038/nrm760.


From sites of transcription in the nucleus to the outreaches of the cytoplasm, messenger RNAs are associated with RNA-binding proteins. These proteins influence pre-mRNA processing as well as the transport, localization, translation and stability of mRNAs. Recent discoveries have shown that one group of these proteins marks exon exon junctions and has a role in mRNA export. These proteins communicate crucial information to the translation machinery for the surveillance of nonsense mutations and for mRNA localization and translation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cytoplasm / metabolism
  • Exons
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Humans
  • Models, Biological
  • RNA Splicing
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / metabolism*
  • Ribonucleoproteins / metabolism


  • Heterogeneous-Nuclear Ribonucleoproteins
  • RNA, Messenger
  • RNA-Binding Proteins
  • Ribonucleoproteins
  • messenger ribonucleoprotein