Matrix metalloproteinases: a tail of a frog that became a prince

Nat Rev Mol Cell Biol. 2002 Mar;3(3):207-14. doi: 10.1038/nrm763.


It is 40 years since the first member of what came to be known as the matrix metalloproteinase (MMP) family was described. Structural, molecular and biochemical approaches have subsequently contributed to piecing together the puzzle of how MMPs work, and how they contribute to various disease processes.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cloning, Molecular
  • Gene Expression Regulation, Enzymologic
  • History, 20th Century
  • Humans
  • Matrix Metalloproteinases / chemistry
  • Matrix Metalloproteinases / genetics
  • Matrix Metalloproteinases / history
  • Matrix Metalloproteinases / physiology*
  • Models, Biological
  • Models, Molecular
  • Protease Inhibitors / therapeutic use


  • Protease Inhibitors
  • Matrix Metalloproteinases