Evolutionary conservation of microtubule-capture mechanisms

Nat Rev Mol Cell Biol. 2002 Apr;3(4):296-304. doi: 10.1038/nrm777.


The dynamic nature of microtubules allows them to search the three-dimensional space of the cell. But what are they looking for? During cellular morphogenesis, microtubules are captured at sites just under the plasma membrane, and this polarizes the microtubule array and associated organelles. Recent data indicate that the signalling pathways that are involved in regulating the different microtubule cortical interactions are not only conserved between species, but also that they function in diverse processes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Evolution*
  • Cell Polarity / physiology
  • Fibroblasts / physiology
  • Microtubule-Organizing Center / physiology
  • Microtubules / physiology*
  • Models, Biological
  • Saccharomyces cerevisiae / physiology
  • Signal Transduction
  • Tubulin / physiology


  • Tubulin