Molecular mechanisms of "detachment-induced apoptosis--Anoikis"

Apoptosis. 2002 Jun;7(3):247-60. doi: 10.1023/a:1015312119693.


Apoptosis following loss of cell anchorage is of relevance for development, tissue homeostasis and disease. In the following the role of cell-matrix anchorage as well as cell-cell anchorage for cell survival and apoptosis is reviewed and the complex molecular mechanisms inducing and perpetuating detachment-induced apoptosis will be discussed with special emphasis on the role of caspases, p53, bcl-2 family members and the Fas signaling pathway.

Publication types

  • Review

MeSH terms

  • Anoikis / physiology*
  • Apoptosis / physiology*
  • Cadherins / metabolism
  • Caspases / metabolism
  • Cell Adhesion / physiology
  • Cell Survival
  • Cell Transformation, Neoplastic
  • Homeostasis*
  • Models, Biological
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Signal Transduction / physiology
  • Tumor Suppressor Protein p53 / metabolism
  • fas Receptor / metabolism


  • Cadherins
  • Proto-Oncogene Proteins c-bcl-2
  • Tumor Suppressor Protein p53
  • fas Receptor
  • Caspases