Effectiveness of second-generation fibrin glue in endonasal operations

Otolaryngol Head Neck Surg. 2002 Apr;126(4):388-91. doi: 10.1067/mhn.2002.123345.


We evaluated the efficacy and safety of the Quixil fibrin sealant after its application to endonasal operative sites. A total of 153 patients underwent nasal surgery. The rate of hemorrhagic complications was compared in the group with nasal packing and in the group in whom fibrin glue was used to stop postoperative bleeding. Our results indicate that the application of Quixil fibrin glue to the operative sites in various endonasal operations provides effective hemostasis and sealing. This fibrin glue is a more effective hemostatic agent than foam nasal packing and provides no complications, as can occur with packing. Patients with hypertension have no greater risk for postoperative bleeding if Quixil is used.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Female
  • Fibrin Tissue Adhesive / therapeutic use*
  • Hemostatics / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Nasal Septum / surgery
  • Nose Diseases / surgery*
  • Postoperative Hemorrhage / prevention & control*
  • Prospective Studies
  • Tampons, Surgical


  • Fibrin Tissue Adhesive
  • Hemostatics