Postprandial elevation of remnant lipoprotein leads to endothelial dysfunction

Circ J. 2002 Feb;66(2):127-32. doi: 10.1253/circj.66.127.


Recent studies have demonstrated that elevated levels of cholesterol in the form of remnant-like particles (RLP-C) induce deterioration of endothelial function during the fasting state, but it is not known whether postprandial RLP-C elevation has the same effect. The objective of this study was to assess the effect of postprandial RLP-C elevation on endothelial function in 24 fasting normolipidemic subjects. Flow-mediated dilatation (FMD) during reactive hyperemia in the brachial artery was investigated. Serum lipids and lipoproteins during fasting and 4h after regular fat-loading were measured. Subjects were divided into 2 groups: the high responders (postprandial RLP-C level >7.5mg/dl, n=8) and the normal responders (postprandial RLP-C level < or =7.5mg/dl, n=16). Significant increases in the level of both triglycerides and RLP-C were observed in the high responders. Basal FMD in the high responders (4.3+/-3.0%) was significantly lower than that in the normal responders (8.3+/-2.4%) (p<0.01), but FMD after the fat-loading in both groups did not change significantly. The change in RLP-C levels during the fat-loading test correlated significantly with basal FMD (r=-0.588, p<0.01). Multiple regression analysis showed a significant correlation between basal FMD and the change in RLP-C levels (r=-0.488, p<0.02). The results of this study suggest that postprandial RLP-C elevation could be associated with atherosclerotic progression even in normolipidemic subjects.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Apolipoproteins / blood
  • Biomarkers / blood
  • Blood Pressure
  • Cholesterol / blood*
  • Cholesterol, HDL / blood
  • Endothelium, Vascular / physiopathology*
  • Fasting
  • Female
  • Humans
  • Hypertension / blood
  • Lipoproteins / blood*
  • Male
  • Middle Aged
  • Peptide Fragments / blood*
  • Postprandial Period
  • Reference Values
  • Triglycerides / blood*


  • Apolipoproteins
  • Biomarkers
  • Cholesterol, HDL
  • Lipoproteins
  • Peptide Fragments
  • Triglycerides
  • remnant-like particle cholesterol
  • Cholesterol