Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder

Ann N Y Acad Sci. 2001 Mar;933:323-9. doi: 10.1111/j.1749-6632.2001.tb05836.x.

Abstract

Various types of evidence implicate nitric oxide and an oxidant, possibly peroxynitrite, in MCS and chemical intolerance (CI). The positive feedback loops proposed earlier for CFS may explain the chronic nature of MCS (CI) as well as several of its other reported properties. These observations raise the possibility that this proposed elevated nitric oxide/peroxynitrite mechanism may be the mechanism of a new disease paradigm, answering the question raised by Miller earlier: "Are we on the threshold of a new theory of disease?"

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Arginine / biosynthesis
  • Blood-Brain Barrier / drug effects
  • Cholinesterase Inhibitors / adverse effects
  • Cholinesterase Inhibitors / pharmacology
  • Cytokines / metabolism
  • Enzyme Induction / drug effects
  • Enzyme Inhibitors / pharmacology
  • Fatigue Syndrome, Chronic / etiology*
  • Fatigue Syndrome, Chronic / metabolism
  • Feedback
  • Humans
  • Inflammation / chemically induced
  • Inflammation / physiopathology
  • Insecticides / adverse effects
  • Insecticides / pharmacology
  • Kindling, Neurologic / drug effects
  • Models, Animal
  • Models, Biological
  • Multiple Chemical Sensitivity / etiology*
  • Multiple Chemical Sensitivity / metabolism
  • Neopterin / biosynthesis
  • Nitric Oxide / physiology*
  • Nitric Oxide Synthase / antagonists & inhibitors
  • Nitric Oxide Synthase / metabolism
  • Nitric Oxide Synthase Type II
  • Organophosphorus Compounds
  • Oxidation-Reduction
  • Oxidative Stress
  • Peroxynitrous Acid / physiology*
  • Receptors, Muscarinic / biosynthesis
  • Receptors, Muscarinic / physiology
  • Stress Disorders, Post-Traumatic / etiology*
  • Stress Disorders, Post-Traumatic / metabolism
  • Up-Regulation / drug effects
  • Xenobiotics / adverse effects
  • Xenobiotics / pharmacology

Substances

  • Cholinesterase Inhibitors
  • Cytokines
  • Enzyme Inhibitors
  • Insecticides
  • Organophosphorus Compounds
  • Receptors, Muscarinic
  • Xenobiotics
  • Peroxynitrous Acid
  • Nitric Oxide
  • Neopterin
  • Arginine
  • NOS2 protein, human
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type II