Impaired glucose tolerance as a determinant of early deterioration of left ventricular diastolic function in middle-aged healthy subjects

Am J Cardiol. 2000 Mar 15;85(6):790-2, A9. doi: 10.1016/s0002-9149(99)00866-8.


To clarify the determinants of an abnormal relaxation diastolic pattern assessed by Doppler echocardiography, 131 middle-aged healthy subjects were analyzed. By multivariate logistic regression analysis, fasting insulin levels (p = 0.0016) and peak glucose levels (p = 0.046) were independent predictors of an abnormal relaxation diastolic pattern 2 hours after 75 g OGTT.

MeSH terms

  • Diastole / physiology
  • Female
  • Glucose Intolerance*
  • Glucose Tolerance Test
  • Humans
  • Insulin Resistance
  • Male
  • Middle Aged
  • Ventricular Dysfunction, Left / diagnosis
  • Ventricular Dysfunction, Left / physiopathology*