Abstract
[structure: see text] An efficient and highly convergent synthesis of the FGHIJKLMN ring fragment of gymnocin A, a cyctotoxic polycyclic ether isolated from the notorious red-tide forming dinoflagellate Gymnodinium mikimotoi, has been achieved. The present synthesis relied on extensive use of the B-alkyl Suzuki-Miyaura coupling reaction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Dinoflagellida / drug effects*
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Ethers, Cyclic / chemical synthesis*
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Ethers, Cyclic / isolation & purification
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Indicators and Reagents
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Models, Molecular
Substances
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Antineoplastic Agents
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Ethers, Cyclic
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Indicators and Reagents
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gymnocin A