Lactobacillus fermentum RC-14 inhibits Staphylococcus aureus infection of surgical implants in rats

J Infect Dis. 2002 May 1;185(9):1369-72. doi: 10.1086/340126. Epub 2002 Apr 5.


Staphylococcus aureus is a common cause of community and hospital-acquired infections. Moreover, the clinical impact of S. aureus is on the rise because of the global increase in the incidence of multidrug-resistant strains and its growing prevalence as a major cause of surgical infections. As a result, there is a pressing need to identify new antistaphylococcal agents and preventative strategies that will help in the management of these types of infections. This report describes the successful use of a probiotic, Lactobacillus fermentum RC-14, and its secreted biosurfactant to inhibit surgical implant infections caused by S. aureus. L. fermentum RC-14 and its secreted biosurfactant both significantly inhibited S. aureus infection and bacteria adherence to surgical implants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacterial Adhesion
  • Lactobacillus / physiology*
  • Male
  • Prostheses and Implants / adverse effects*
  • Rats
  • Rats, Sprague-Dawley
  • Staphylococcal Infections / prevention & control*
  • Staphylococcus aureus / isolation & purification*