Notching up another pathway

Bioessays. 2002 May;24(5):405-10. doi: 10.1002/bies.10089.


The Notch proteins play a vital role in cell fate decisions in both invertebrate and vertebrate development. Careful analysis of this role has led to a model of signalling downstream of these receptors, via the CSL (CBF1, Suppressor of Hairless, Lag-1) family of transcription factors. There have been suggestions, however, that Notch can signal through other pathways. In the current paper, Ramain et al. provide compelling evidence for Notch signalling through a CSL-independent pathway and they demonstrate that the cytoplasmic protein, Deltex, is required for this signal. In addition, they show that Wnt signalling may regulate this Deltex-dependent signal.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alleles
  • Animals
  • Cell Differentiation
  • Cell Membrane / metabolism
  • Drosophila
  • Drosophila Proteins*
  • Humans
  • Insect Proteins / physiology*
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Models, Biological
  • Models, Genetic
  • Phenotype
  • Receptors, Notch
  • Signal Transduction


  • DX protein, Drosophila
  • Drosophila Proteins
  • Insect Proteins
  • Membrane Proteins
  • N protein, Drosophila
  • Receptors, Notch