NF-kappaB in Cancer: From Innocent Bystander to Major Culprit

Nat Rev Cancer. 2002 Apr;2(4):301-10. doi: 10.1038/nrc780.

Abstract

Nuclear factor of kappaB (NF-kappaB) is a sequence-specific transcription factor that is known to be involved in the inflammatory and innate immune responses. Although the importance of NF-KB in immunity is undisputed, recent evidence indicates that NF-kappaB and the signalling pathways that are involved in its activation are also important for tumour development. NF-kappaB should therefore receive as much attention from cancer researchers as it has already from immunologists.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Lymphatic Diseases / metabolism
  • Models, Biological
  • NF-kappa B / biosynthesis*
  • Neoplasms / metabolism*
  • Signal Transduction*

Substances

  • NF-kappa B