New hope for an AIDS vaccine

Nat Rev Immunol. 2002 Apr;2(4):239-50. doi: 10.1038/nri776.


The twenty-first century has begun with considerable success for new AIDS vaccines in macaque models. A common feature of these vaccines is their ability to induce high-frequency CD8+ T-cell responses that control, rather than prevent, infection with HIV. The new vaccines, which include DNA vaccines and live viral vectors, are based on technologies that have been developed since the start of the AIDS epidemic. The ultimate promise of these vaccines will be realized only when efficacy trials in humans are conducted.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AIDS Vaccines / administration & dosage*
  • AIDS Vaccines / genetics
  • AIDS Vaccines / immunology
  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / prevention & control*
  • Animals
  • CD8-Positive T-Lymphocytes / immunology*
  • Clinical Trials as Topic
  • Drug Design
  • Forecasting
  • Genetic Vectors
  • HIV-1 / immunology*
  • Humans
  • Macaca
  • Vaccines, DNA / immunology


  • AIDS Vaccines
  • Vaccines, DNA